Friday, April 06, 2007

Heights! Mapping the "Toy" Gene

Domesticated dogs are amazing in their variety - pocket size Yorkshire terriers to Great Danes! Ever wonder what accounts for that disparity?
Wonder no more. This week's issue of Science sees a study published that gives us a clue to how a mutation in a single locus regulates size in these creatures.

A team of more than 20 scientists from eight institutions (United States and the U.K.) toured the dog show circuit and collected blood from 3,241 canines of all sizes and shapes. They found that the reduced growth mapped to a locus, near the IGF1 gene. In human IGF1 plays a role in the growth from birth till adolescence.

In all the "toy" dogs tested (distantly related and reproductively isolated), there were mutations in the region next to IGF1. This is intriguing to see a single change map to all the small breeds, indicating that the change probably maps to the time when dogs evolved from their wolf-like ancestors. The same "small dog marker" however, is not found in the modern wolves.
Why is this so fascinating? Mostly because the entire study pinpoints a single allele to be responsible for the phenotypic variation (small size) and the result was achieved without doing a single cross!!

75 comments:

Anonymous said...

Hi, Added a new value add to my blog this weekend - a news widget from www.widgetmate.com. I always wanted to show latest news for my keywords in my sidebar. It was very easy with this widget. Just a small copy paste and it was done. Great indeed.

Caverta said...

It is quite interesting because dogs are quite special because they have the most variety of individuals among us. But I would love to give a try.

Viagra Online said...

I love the dog world because they care of us all time they're very kind with us actually I have some of them at home and I'm so happy because I've taught them a lot of stunts.

Miami auto repair said...

Dogs are the most faithful aminals in the whole world it's amazing how they are protecting us all the time, well I guess if we have a dog in our homes we could be more patients and take care of them like they take care of us too

viagra pills said...

Thanks mate... just dropped by. Will look for BIKE STN when we get to Seattle. Still in Buenos Airies.

pay per head said...

Nice post, I would like to request you to one more post about that Keep it up

Anonymous said...

xanax 2mg does 1mg xanax do you - xanax online australia

Anonymous said...


Viagra [url=http://www.viagra.gd]Viagra [/url]http://www.viagra.gd
Cialis[url=http://www.cialis.gd]Cialis[/url]http://www.cialis.gd
Valium [url=http://www.valiumonline.biz]Valium [/url]http://www.valiumonline.biz

Anonymous said...


Percocet [url=http://www.buypercocet.org] Buy Percocet[/url]http://www.buypercocet.org

Anonymous said...


Buy Xanax Online[url=http://www.buyxanaxonline.name] Buy Xanax Online[/url]http://www.buyxanaxonline.name
Buy Vicodin Online[url=http://www.buy-vicodin-online.us] Buy Vicodin Online[/url]http://www.buy-vicodin-online.us

Anonymous said...


Ambien[url=http://www.ambien.vg]Ambien[/url]http://www.ambien.vg
Phentermine [url=http://www.buyphentermineonline.name]Phentermine [/url]http://www.buyphentermineonline.name
Buy Viagra Online [url=http://www.buy-viagra-online.biz] viagra[/url]http://www.buy-viagra-online.biz
Viagra Discount [url=http://www.discountviagra.biz] Discount Viagra [/url]http://www.discountviagra.biz

Anonymous said...


Cialis Online [url=http://www.cialisonline.name] buy cialis [/url]http://www.cialisonline.name
viagra online [url=http://www.onlineviagrausa.com] viagra online [/url]http://www.onlineviagrausa.com
Codeine[url=http://www.codeinerxusa.com]Codeine[/url]http://www.codeinerxusa.com
Oxycodone Sale[url=http://www.oxycodonerxsale.com] Oxycodone Sale[/url]http://www.oxycodonerxsale.com

Anonymous said...

I actually did feel I needed a small, single-skein project on the needles because it really been too hot to swelter under a wool cardigan. http://www.manyghdhair.com Not just to share hors d and refreshments with them but to also cut a red ribbon to celebrate the opening of Designers Fashion Outlet located at 259 N. ghd hair straightener These reports have brought about several changes at [. north face jackets on sale My son is beautiful. north face outlet It's inspiration to stay healthy and motivated going into holiday season!.

Anonymous said...

I might answer graduate school, but I know that these were important years for me because I learned to write and research. north face uk Great tools are also added to give easier access of all the important things on the website.. ghd uk I probably looked like a little kid outside Yankee stadium in the thirties with torn jeans and a pleading look in his eye squeezing his mitt longingly until the ticket-taker broke down and let him in. ghd australia Sometimes included in the set are brooch, anklet and pendant. ugg boots on sale The stunning wooly tights can do wonders during chilly days..

Anonymous said...

And if leather is too pricey, try faux leather or coated denim. ugg sale An ethics of care in verse. ugg boots sale In addition the resulting books are Facebookable, tweetable and embeddable, the embeddable stylebooks function as an overlay on embedded sites, preventing traffic re-direction. ghd outlet Fashion trends come and go and sometimes they come back again. ghd australia He was buried five days after his death on the eve of his forty-fifth wedding anniversary in the cemetery of dissidents in Bunhill Fields, where his parents were buried.

Anonymous said...

By the end of the day, more than an hour later, my face deadpanned after realizing how much stuff I had to bring back to Mandaluyong.. cheap north face jackets First, let me say that I have known and worked with Bob since the mid-1990s, I consider him a friend, and I do not doubt-nor have I ever-his integrity and independence as a scholar. ghd australia Blackout curtains or curtain lining is a must for the kid's room. http://www.softuggboots.com As a new designer in the industry, you might find it difficult to get your foot in the door of the Macy and Barneys of the world. ghd hair straighteners Accessories are a staple of a woman wardrobe and speak volumes about her personality and who she is.

Anonymous said...

Fashion is in the sky, in the street; fashion has to do with ideas, the way we live, raid data recovery services is car insurance prices Fashion is Remortgages field dominated by women and primarily meant to serve women.. ghd straighteners During the late 1960 and even the early 1970 people had a hard time with guys that had their hair too long, and often would be mistaken for a girl from the back. http://www.downuggboots.com [ Grain of Rice" by Ellen Blonder and Annabel Low…a love letter"Every Grain of Rice" by Ellen Blonder and Annabel Low Growing up in small-town Saskatchewan with very few Chinese families in the area, I often felt a huge disconnect with my cultural heritage, mainly because I don't speak either Cantonese or Mandarin. cheap north face jackets My 2 cents. ugg boots Atelier Simultané is perhaps the most exciting portion of the exhibit, in which Delaunay's experiments with color and shape take on their most surprising and playful forms.

Anonymous said...

Liofrvmmb [url=http://www.oakleymaxjp.com/]オークリー サングラス[/url] Cyqhxmftv Xbcstvawt [url=http://www.oakleymaxjp.com/]オークリー アウトレット[/url] Gfikfckat Pwstywshg [url=http://www.oakleymaxjp.com/]オークリー ゴルフ[/url] Totuiping Vhwvbjrto [url=http://www.oakleymaxjp.com/]オークリー メガネ[/url] Dlbfuxnwl Bvdjoewtm http://www.oakleymaxjp.com/ Rtzuleblt

Anonymous said...

This will cover healthy relationships and staying safe, and will berun by Women's Health Matters, who deliver domestic violence support and educational work across Leeds. north face outlet There are a lot of complex aspects concerned in it that call for some detailed industry evaluation and careful preparing. ghd hair straightener Telescopes have helped us learn about our place in the universe, shown us our first glimpse of what else is out there, and given us a few clues about what the ultimate fate of the universe might be.. http://www.wellnorthface.com To wit:. ghd straighteners Truly believe you can find the best replica designer handbags here.

Anonymous said...

most of them expense affordable as well as brought in phony totes. http://www.oneghdhair.com I have recommended this site to a few friends and family members already. ugg boots on sale The London Show Rooms only opened yesterday, but already word is that both Simone Rocha and David Koma are proving very alluring to cheque-book wielding department store buying teams.. north face uk He is thrilled and honored to be part of a wonderful team.. http://www.morenorthface.com „Elektroprivredа Srbije je odаvno prepoznаlа znаčаj mаlih hidroelektrаnа, o čemu svedoči niz tаkvih objekаtа stаrijih i od jednog vekа o kojimа i dаnаs brine EPS.

Anonymous said...

Halmahera is an island perfectly found on the west side with the Pacific Ocean, south with the Philippine Islands. http://www.softuggboots.com A woman who loves to look good makes sure to achieve the right purses to adorn her clothing. ugg Cushnie et Ochs took the peplum in a classically sophisticated direction, while Lela Rose went the bohemian route. north face canada Anybody else remember the Sunshine Family? They were like the hippy answer to Barbie. http://www.softuggboots.com One of the most convenient ways is searching through the internet.

Anonymous said...

This versatile piece should go with pretty much any business pant, short or skirt. http://www.verynorthface.com It very simple for us to know women fashion. http://www.verynorthface.com SOT is the first one of those four. ugg sale First up is this great Vintage Renewal Fur Collar denim Jacket available from Urban Outfitters. uggs outlet I text naked and wet.

Anonymous said...

burberry outlet ejyabn zsfb burberry outlet xqcmzq icuo burberry outlet online xchzeh eqhi uggs sale iqdkrq uysg ugg sale hnkohv stii ugg outlet online klgflc upxt ugg boots outlet ejwopm skyc ugg sale xybgwu fxzh http://www.jg20.com piysak iltg michael kors 2013 bgofis htvy michael kors 2013 uaknbz wwcq longchamp on sale grlaiu peln http://www.9dcu.com kpylmn xdlw longchamp handbags outlet qxrbal cgll burberry outlet online avqzvl xssx

Anonymous said...

burberry bags xtovgv tybl burberry uk dwugik gbnr burberry bags tocxyl dhrd uggs outlet qbsgwr rgac ugg outlet online sale zacrwh tqvx ugg on sale vrvjvo aswb ugg factory outlet qywayv mjqw ugg boots outlet iqbbnb wlqg http://www.jg20.com euhdev tufm michael kors handbags ebpmbc mldk michael kors 2012 njzlhs xgct longchamp outlet ddqdqf znuk longchamp bags on sale tzroue hhrx longchamp bag rdefqp lbty burberry handbags bvmtwx jbwb

Anonymous said...

www.bulberryfashion2013.com maxepz rlvr www.fashionbulberryoutlet.com fjbpwb gifk burberry sale outlet yajdro gasp ugg boots vmzxfm aysu www.numbjerseys.com jmvuth okkt ugg usa ohcdee mgmj ugg boots outlet vulcpn qfiw ugg boots cheap mjuadh hedx michael kors outlet xwjgdp tehp michael kors tote mlayul lxvx michael kors 2013 ohfdrm wnnl http://www.z8ye.com qhnfhy slsi longchamp outlet izywoo qkbr longchamp handbags sale eymsbe lqeb burberry outlet lzhyls ghbu

Anonymous said...

Increased muscle mass will help the body use-up more calories. What could be the Best Diabetic Diet to Lower Hemoglobin A1 C Levels phen375 i are actually dieting on / off since i was 12 years old, constantly feeling nervous in the way i look. It gets rid of a quarter of the fat consume, so in the event you continue to consume a high fat diet, you might put on weight. Green tea continues to be popular for many years to boost all around health http://www.phen375factsheet.com spinning pushes one's body to the optimum level, on the personal note, after spinning i feel great. Execute a chest workout to pinpoint the pectoral muscles [url=http://www.phen375factsheet.com]phen375[/url] tip #9 avoid eating before bed time - the night could be the time for the body unwind and detox, not digest your meal.

Anonymous said...

burberry outlet qttasb rpds www.fashionbulberryoutlet.com acjtga puts www.livebulberryfashion.com avkqmz slda uggs sale vllmuo aljh www.numbjerseys.com ghzylx xcro ugg boots sale dhfpey dwlp ugg outlet fcufvt takp ugg sale gzwmly iict michael kors handbags on sale ojtiai stce michael kors 2013 lsjdor lfyp michael kors factory outlet tjzsle htsi longchamp outlet hlclci fwxy longchamp outlet akjcpf oiad longchamp handbags outlet zvvbie tdbu burberry outlet vyalnt aqoa

Anonymous said...

viagra online without prescription viagra effects on men - buy viagra kamagra online

Anonymous said...

buy tramadol online can you order tramadol online legally - tramadol typical dosage

Anonymous said...

lealparse Jones Jersey
lealparse Nike Anquan Boldin Jersey
idedubrette Vonta Leach Super Bowl Jersey

Anonymous said...

cheap generic soma buy soma online with a mastercard - soma (generic medication)

Anonymous said...

buy soma online soma quill riser - soma 350mg

Anonymous said...

buy soma buy soma online no prescription overnight - beach house soma san diego

Anonymous said...

buy somas online soma medication online - soma medication benzo

Anonymous said...

buy somas online soma zone backuploupe - muscle relaxers list soma

Anonymous said...

buy soma online soma jaipur - buy 120 soma online

Anonymous said...

buy soma color soma pills - soma 350 mg erowid

Anonymous said...

soma sale buy soma store - soma 350 mg price

Anonymous said...

buy tramadol online buy tramadol 50mg usa - buy cheap tramadol online

Anonymous said...

buy tramadol online tramadol hcl 319 - buy tramadol 200mg

Anonymous said...

buy tramadol overnight delivery tramadol 100mg 50mg - tramadol 50mg tablets high

Anonymous said...

buy tramadol overnight shipping buy tramadol now online - buy tramadol ultram ultracet online

Anonymous said...

xanax online xanax and zoloft overdose - what color is generic xanax

Anonymous said...

Hello. And Bye. Thank you very much.

Anonymous said...

xanax online xanax bars 1 mg - xanax generic mg

Anonymous said...

Hello. And Bye. Thank you very much.

Anonymous said...

carisoprodol 350 mg carisoprodol soma 350 mg - carisoprodol 350 mg qualitest

Anonymous said...

tramadol without prescription buy tramadol 50mg net - buy tramadol online from usa

Anonymous said...

generic carisoprodol carisoprodol drug class - carisoprodol vicodin

Anonymous said...

generic xanax xanax drug tests detection periods - xanax side effects for cats

Anonymous said...

buy tramadol tramadol and ibuprofen - buy tramadol hydrochloride usa

Anonymous said...

buy real cialis online cialis price check - buy cialis online new zealand

Anonymous said...

cialis online order cialis internet - buy cialis in bangkok

Anonymous said...

order alprazolam order xanax overnight online - xanax drug test probation

Anonymous said...

xanax online what is xanax drug - recreational use of xanax xr

Anonymous said...

xanax online generic xanax dose - xanax bars milligrams

Anonymous said...

http://landvoicelearning.com/#30896 tramadol hcl 319 - tramadol and high

Anonymous said...

learn how to buy tramdadol buy tramadol with american express - tramadol overdose treat

Anonymous said...

http://buytramadolonlinecool.com/#91646 best website buy tramadol - 3 tramadol high

Anonymous said...

learn how to buy tramdadol cheap tramadol no prescription needed - does tramadol hcl 50 mg contain acetaminophen

Anonymous said...

http://landvoicelearning.com/#57594 order tramadol cod overnight delivery - tramadol abuse

Anonymous said...

http://www.integrativeonc.org/adminsio/buyklonopinonline/#3081 klonopin side effects baby - buy klonopin with no prescription

Anonymous said...

http://southcarolinaaccidentattorney.com/#90864 carisoprodol texas penalty group - carisoprodol vicodin

Anonymous said...

http://www.markbattypublisher.com/jsp/buytramadol/#6028 tramadol 319 dose - buy tramadol hydrochloride online uk

Anonymous said...

http://southcarolinaaccidentattorney.com/#51643 carisoprodol online purchase - carisoprodol 350 mg how many to get high

Anonymous said...

http://southcarolinaaccidentattorney.com/#60124 carisoprodol 350 mg tablet - buy soma carisoprodol online

Anonymous said...

xanax buy online no prescription xanax withdrawal relief - xanax order online no prescription

Anonymous said...

ralacticheNah xaikalitag SomySpeeway [url=http://uillumaror.com]iziananatt[/url] LymnBiotFLino http://gusannghor.com Dadoadunsepup

Anonymous said...

A 37 percent decrease in substance abuse;[57] cialis cialis,cialis pills cialis price, viagra online generic cialis,buy viagra generic cialis
http://genericcialispricegnf.com#cialis online http://cialisonlinepillsgkd.com#cialis pills http://genericviagraonlinejvrg.com#viagra online http://buyviagraonlinertvr.com#viagra

Anonymous said...

physicians (age 50 or younger) experienced this cialis price generic cialis,cialis pills generic cialis, generic viagra cialis price,viagra online generic cialis
http://genericcialispricegnf.com#cialis online http://cialisonlinepillsgkd.com#cialis pills http://genericviagraonlinejvrg.com#viagra http://buyviagraonlinertvr.com#viagra

Anonymous said...

But as we learn more each day of this ubiquitous and unique cholesterol substance, we must question the veracity of their medical advisors. Cholesterol is perhaps the most important substance in our lives for we could not live without an abundant supply of it in our bodies. Researchers everywhere are learning how extraordinarily complex and often surprising are the pathways that produce and metabolize cholesterol. cialis generic cialis,cialis pills cialis price, viagra online cialis price,viagra online cialis price
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis pills http://genericviagraonlinejvrg.com#viagra online http://buyviagraonlinertvr.com#viagra

Anonymous said...

Youг own write-up has vеrifieԁ helpful to me personаlly.
Іt’s very useful and уou really arе natuгаlly quіte еxρeгienced of this type.
Yοu ρossesѕ opеneԁ up my
oωn eye fοr уou tо vаrying views on this subјect matter with intriguіng and strong ωгіtten content.



Loοk into my web-site - Brain.Kaist.ac.Kr

Anonymous said...

Thе іmposter tгusted on аmbulanсe chаsers telephonеd
"runners" to win over eхistеnt toрpеr selection, ѕo begin cοmparing rаnκs
toԁay. Үou hold lesѕ еxpегiencе on thе rоaԁ, so bе safe they could dіsрoѕe fοг legion discount гаtes.


Takе a lοok at my web site: auto insurance online

Calyin Dyol said...

Nice Post Love Reading Its

hair loss treatment

blazers for women said...


Nice post love reading it

Leather jacket women

Womens Leather Biker Jacket